Eating well on the Planet Earth
"Let food be thy medicine and medicine be thy food." ...Hippocrates

Ergocalciferol (Vitamin D2)

There are two main forms of Vitamin D that are biologically active in humans. Vitamin D3, or cholecalciferol is the type that is produced by the skin when it is exposed to sunlight. Humans synthesize this vitamin and it is also available in some animal food sources such as fatty fish, eggs, and liver. Milk and some cereals are fortified with Vitamin D3. The other form, D2, is ergocalciferol. This form of vitamin D is found in certain plants, which classifies it as a phytonutrient. Although Vitamin D requirements generally can include both these sources and they are both usuable by the body, I am focusing on the phytonutrient ergocalciferol on this page.

Certain plants synthesize ergosterols, which can be converted to ergocalciferol when they are exposed to ultraviolet light. Ergosterol performs the same functions in the membranes of fungus cells as cholesterol does in the cells of animals. In animals, cholesterol is the compound that is converted into cholecalciferol, or Vitamin D3. The best dietary source of ergocalciferol, since we don't eat a huge variety of fungus, is mushrooms. However they need to have some exposure to ultraviolet light either while they are growing or shortly after they are picked to convert the ergosterol into ergocalciferol. If this is a dietary concern of yours, perhaps if you don't eat any animal products including milk and eggs, and you have very little exposure to sunlight, it's a good idea to find a source of mushrooms that grows them with ultraviolet exposure. One such place is Monterey Mushrooms in Watsonville, California.

Apparently both forms of Vitamin D perform the same functions in the body, once they are finally converted into a usable form. This form is either calcitriol or calcidiol, both potent steroid hormones which are necessary for calcium absorption, bone growth and maintenance, neurological and immune system functions, and reducing inflammation. Vitamin D is also a subject of research as a treatment or prevention for Addison's Disease, allergic hypersensitivity, Alzheimer's, asthma, Ankylosing Spondylitis, autism, autoimmune disease such as rheumatoid arthritis, several cancers, COPD, systic fibrosis, depression, and other conditions. You can see how widespread and important this vitamin is to our health, affecting nearly every major system. I haven't been able to find any research that points to specific benefits of ergocalciferol over cholecalciferol. Many studies have used ergocalciferol as the test substance, but didn't follow up by comparing the effects with cholecalciferol. The two appear to be used interchangeably by researchers.

On the flip side, research suggests that cholecalciferol is actually superior to ergo as a source of Vitamin D. One such study was reported in the American Journal of Clinical Nutrition in October of 2006. This study acknowledged that D2 has been able to effectively treat rickets in children and heal osteomalacia in adults. However it found that D3 absorbs much more quickly into the sytem, D2 was has not been found to prevent fractures in clinical trials, and D2 is not metabolized as efficiently as D3. Therefore if you are taking a VitaminD supplement they recommend making sure it is D3, or cholecalciferol.

Who would be interested in D2? Well, D2 is derived from plant sources, fungus to be precise, while commercial D3 is harvested from the fat in lambs wool, and the only dietary sources of D3 are animal products. Therefore if you are a strict vegan and prefer not to use any animal products, ergocalciferol would be a good choice for your Vitamin D supplement. Also, you would be wise to make sure you get enough sun exposure for your skin to manufacture this vitamin.

In other areas on this site you can find basic information about Vitamin D, your daily requirement for Vitamin D, and information about rickets.

Return to Phytonutrients

The information on this page is not meant to be used in treatment of medical conditions. Please seek the advice of a physician about any medical condition or symptom. Those with medical conditions should consult a medical professional about the appropriateness of taking dietary supplements or diet therapy, and how these methods will interact with their medications.

The Vitamin D Council